The papers listed below are the most frequently downloaded papers for the 12 months to the end of August 2009

Downloads	Title / Authors
8330	Polyunsaturated fatty acid-specific elongation enzymes T. Das, J. M. Thurmond, E. Bobik, A. E. Leonard, J. M. Parker-Barnes, Y.-S. Huang and P. Mukerji Abstract | Legacy HTML | Full text PDF
5115	Wellcome Trust Award Lecture Integrin Structure M. J. Humphries Abstract | Legacy HTML | Full text PDF
4750	Sir Frederick Gowland Hopkins Medal Lecture Pleasant Surprises En Route from the Biochemistry of Collagen to Attempts at Gene Therapy D. J. Prockop Legacy HTML | Full text PDF
4246	The ubiquitin–proteasome pathway regulates lysosomal degradation of the growth hormone receptor and its ligand P. van Kerkhof and G. J. Strous Abstract | Legacy HTML | Full text PDF
4172	Peroxisomal fatty acid a- and b-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases R. J. A. Wanders, P. Vreken, S. Ferdinandusse, G. A. Jansen, H. R. Waterham, C. W. T. van Roermund and E. G. Van Grunsven Legacy HTML | Full text PDF
3920	How do microRNAs regulate gene expression? Ian G. Cannell1, Yi Wen Kong1 and Martin Bushell Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3892	VEGF signalling: integration and multi-tasking in endothelial cell biology I. Zachary Abstract | Legacy HTML | Full text PDF
3599	Lipoprotein oxidation and atherosclerosis I. S. Young and J. McEneny Abstract | Legacy HTML | Full text PDF
3460	Jubilee Lecture The Chemical and Biological Versatility of Riboflavin V. Massey Abstract | Legacy HTML | Full text PDF
3424	Novartis Medal Lecture Rho GTPases and the control of cell behaviour A. Hall Abstract | Legacy HTML | Full text PDF
3408	Coping with stress: eIF2 kinases and translational control R.C. Wek, H.-Y. Jiang and T.G. Anthony Abstract | Legacy HTML | Full text PDF
3333	Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications C. Alarcón de la Lastra1 and I. Villegas Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3307	FOXO transcription factors: key regulators of cell fate E.W.-F. Lam, R.E. Francis and M. Petkovic Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3180	Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance Mary C. Sugden and Mark J. Holness Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3095	Keilin Memorial Lecture The molecular machinery of Keilin's respiratory chain P.R. Rich Legacy HTML | Full text PDF
2928	Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain J. Soulé, E. Messaoudi and C.R. Bramham Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2840	Colworth Memorial Lecture Cellular functions of the BRCA tumour-suppressor proteins S.J. Boulton Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2824	Regulation of purine nucleotide biosynthesis: in yeast and beyond R.J. Rolfes Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2801	Regulation of cell–cell adhesion by the cadherin–catenin complex W. James Nelson Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2753	Chemokine inhibition – why, when, where, which and how? Z. Johnson, C.A. Power, C. Weiss, F. Rintelen, H. Ji, T. Ruckle, M. Camps, T.N.C. Wells, M.K. Schwarz, A.E.I. Proudfoot and C. Rommel Abstract | Legacy HTML | Full text PDF
2593	A complex interplay between Akt, TSC2 and the two mTOR complexes Jingxiang Huang and Brendan D. Manning Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2565	The twin-arginine transport system: moving folded proteins across membranes F. Sargent Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2561	Morton Lecture Signalling through Class I PI3Ks in mammalian cells P.T. Hawkins, K.E. Anderson, K. Davidson and L.R. Stephen Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2561	Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword? S. Patel, B. Doble and J.R. Woodgett Abstract | Legacy HTML | Full text PDF
2493	Mechanisms of p53-dependent apoptosis M. Schuler and D. R. Green Abstract | Legacy HTML | Full text PDF
2448	Thudichum Medal Lecture L-Glutamate as a Central Neurotransmitter: Looking Back J. C. Watkins Legacy HTML | Full text PDF
2421	HPV: from infection to cancer M.A. Stanley, M.R. Pett and N. Coleman Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2382	NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Cécile Guichard, Richard Moreau, Dominique Pessayre, Terry Kay Epperson and Karl-Heinz Krause Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2306	Role of reactive oxygen species in cell signalling pathways J. T. Hancock, R. Desikan and S. J. Neill Abstract | Legacy HTML | Full text PDF
2290	Interactions of the ergosterol biosynthetic pathway with other lipid pathways M. Veen and C. Lang Abstract | Legacy HTML | Full text PDF
2275	Signalling role of adipose tissue: adipokines and inflammation in obesity P. Trayhurn and I.S. Wood Abstract | Legacy HTML | Full text PDF
2274	Colworth Medal Lecture Discovery of PDK1, One of the Missing Links in Insulin Signal Transduction D. R. Alessi Abstract | Legacy HTML | Full text PDF
2184	Life, death and burial: multifaceted impact of autophagy Lorenzo Galluzzi, Eugenia Morselli, José Miguel Vicencio, Oliver Kepp, Nicholas Joza, Nicolas Tajeddine and Guido Kroemer Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2164	Role of adapters in Toll-like receptor signalling S. Akira, M. Yamamoto and K. Takeda Abstract | Legacy HTML | Full text PDF
2147	Characterization of cancer stem cells in chronic myeloid leukaemia H.G. Jørgensen and T.L. Holyoake Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2146	PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases R. Bordet, T. Ouk, O. Petrault, P. Gelé, S. Gautier, M. Laprais, D. Deplanque, P. Duriez, B. Staels, J.C. Fruchart and M. Bastide Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2140	SUMO: getting it on J. Anckar and L. Sistonen Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2134	C-type lectins on dendritic cells: key modulators for the induction of immune responses Yvette van Kooyk Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2053	Integrin regulation of epidermal growth factor (EGF) receptor and of EGF-dependent responses S. Cabodi, L. Moro, E. Bergatto, E. Boeri Erba, P. Di Stefano, E. Turco, G. Tarone and P. Defilippi Legacy HTML | Full text PDF
2049	Role of miRNA-146a in the regulation of the innate immune response and cancer Andrew E. Williams, Mark M. Perry, Sterghios A. Moschos, Hanna M. Larner-Svensson and Mark A. Lindsay Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2036	Structure and trafficking of NMDA and GABAA receptors F.A. Stephenson Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2035	Stress granules: sites of mRNA triage that regulate mRNA stability and translatability N. Kedersha and P. Anderson Abstract | Legacy HTML | Full text PDF
1975	Nod1 and Nod2 in innate immunity and human inflammatory disorders L. Le Bourhis, S. Benko and S.E. Girardin Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1972	Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes X. Fang and G. Sweeney Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1961	The role of the Wnt signalling pathway in colorectal tumorigenesis J. Behrens Abstract | Legacy HTML | Full text PDF
1951	Toll-like receptors: lessons from knockout mice S. Akira Abstract | Legacy HTML | Full text PDF
1919	Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors K.U. Birkenkamp and P.J. Coffer Abstract | Legacy HTML | Full text PDF
1877	Next-generation sequencing: applications beyond genomes Samuel Marguerat, Brian T. Wilhelm and Jürg Bähler Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1877	SUMO under stress Denis Tempé, Marc Piechaczyk and Guillaume Bossis Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1865	G-protein-coupled receptor signalling through protein networks A.D. Strosberg and C. Nahmias Abstract | Enhanced Full Text | Legacy HTML | Full text PDF